《美國生理學雜志：胃腸和肝臟生理學》發表了涉及胃腸道、肝膽系統和胰腺正常或異常功能的所有研究方面的原創文章。鼓勵作者提交有關這些器官的生長發育、消化、分泌、吸收、代謝和運動的手稿，以及有關免疫和炎癥過程以及影響這些器官的神經、內分泌和循環控制機制的研究報告。特別歡迎使用分子生物學、細胞生物學、免疫學、生物化學和形態學方法的研究報告，這些方法有助于了解這些器官的正常生理學或病理生理學。從分子和細胞事件到整個動物的研究都是合適的。

The American Journal of Physiology: Gastrointestinal and Liver Physiology publishes original articles pertaining to all aspects of research involving normal or abnormal function of the gastrointestinal tract, hepatobiliary system, and pancreas. Authors are encouraged to submit manuscripts dealing with growth and development, digestion, secretion, absorption, metabolism, and motility relative to these organs, as well as research reports dealing with immune and inflammatory processes and with neural, endocrine, and circulatory control mechanisms that affect these organs. Reports of research utilizing molecular biological, cell biological, immunological, biochemical, and morphological approaches that contribute to knowledge of normal physiology or pathophysiology of these organs are especially welcomed. Research ranging from molecular and cellular events to whole animal studies are appropriate.