作為美國心臟病學會的官方期刊和該領域的領導者，JACC發表了關于心血管疾病各方面的原始同行評審臨床和實驗報告。 涵蓋的主題包括冠狀動脈和瓣膜疾病，先天性心臟病，血管手術，心肌病，藥物治療，新的診斷技術，實驗室的研究結果以及新療法的大型多中心研究。 專題討論會，臨床評論和更新，編輯評論和信件是常規特征.JACC還發布在美國心臟病學會年度科學會議上提交的論文摘要以及Bethesda會議關于心血管疾病當前主題的報告和建議。

The official journal of the American College of Cardiology and the leader in its field, JACC publishes original peer-reviewed clinical and experimental reports on all aspects of cardiovascular disease. Topics covered include coronary artery and valve disease, congenital heart defects, vascular surgery, cardiomyopathy, drug treatment, new diagnostic techniques, findings from the laboratory, and large multicenter studies of new therapies. Symposia, clinical reviews and updates, editorial commentary, and letters are regular features.JACC also publishes abstracts of papers presented at the annual scientific sessions of the American College of Cardiology and the reports and recommendations of the Bethesda Conferences on current topics in cardiovascular disease.