《美國腎臟疾病雜志》不僅發表了一系列關于人體腎功能的臨床和基礎研究，而且還描述了這些進展對臨床實踐的影響。覆蓋范圍包括應用生理學、透析/慢性尿毒癥、高血壓、泌尿科、病理學和移植。除同行評審的原創文章和案例報告外，該期刊還包括定期專題，如深入審查相關臨床專題；介紹和討論腎臟活檢教學案例；討論和分析近期重要文章；以及道德、道德、以及與腎臟疾病有關的法律問題。該雜志的網站包括“腎臟病理學圖集”、CME練習、臨床腎臟學教學案例和純網絡病例報告等專有功能。

American Journal of Kidney Diseases not only publishes a broad range of clinical and basic investigations in human renal function but also describes the impact of the advances on clinical practice. Coverage encompasses applied physiology, dialysis/chronic uremia, hypertension, urology, pathology, and transplantation. In addition to peer-reviewed original articles and case reports, the Journal includes regular features such as in-depth reviews of relevant clinical topics; presentation and discussion of renal biopsy teaching cases; discussion and analysis of important recent articles; and forum discussions of ethical, moral, and legal issues related to kidney disease. The Journal''s website includes such exclusive features as "Atlas of Renal Pathology," CME exercises, clinical nephrology teaching cases, and web-only case reports.