《美國生理學-調節，整合和比較生理學雜志》發表了最初的研究，闡明了從分子到人，包括臨床研究在內的生物組織各個層次的生理機制的正常或異常調節和整合。主要重點領域包括轉基因動物的調控；模式生物和比較功能基因組學；發育和組織可塑性；神經體液控制循環和高血壓；局部控制循環；心臟和腎臟一體化；干渴和體積、電解質穩態；食欲和肥胖，中樞神經系統的復雜功能，睡眠和運動；炎癥和細胞因子和溫度調節。編輯們希望吸引來自生理學家的論文，他們在健康和疾病方面有著廣泛的監管、整合和穩態方面的興趣。

The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms and comparative functional genomics; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; appetite and obesity, complex function of the central nervous system, sleep and locomotion; and inflammation and cytokines and temperature regulation. The editors wish to attract papers from physiologists who are united by broad interests in regulation, integration, and homeostasis in health and in disease.