《自然評論化學》旨在涵蓋該領域的傳統核心學科——有機、無機、物理和分析化學——同時也為化學是跨學科研究重要組成部分的非專業人士提供見解。這些主題可能包括但不限于：化學生物學、化學物理、材料科學和納米技術。該雜志還旨在引起讀者對學術研究之外的話題的關注，特別關注化學教育和學術環境之外的研究。評論和觀點是由編輯團隊委托的。該雜志涵蓋的研究領域包括(但不一定限于)：分析化學生物化學催化化學生物學化學教育電化學環境化學綠色化學化學工業無機化學實驗室安全材料化學藥物化學納米技術有機化學有機金屬化學物理化學高分子化學光化學超分子化學表面化學理論化學

Nature Reviews Chemistry aims to cover both the traditional core subjects of the field — organic, inorganic, physical and analytical chemistry — while also providing insight to non-specialists where chemistry is a significant component of interdisciplinary research. These topics may include but are not limited to: chemical biology, chemical physics, materials science and nanotechnology. The journal also aims to bring to the attention of its readers topics beyond academic research with particular focus on chemistry education and research outside the academic environment.Reviews and Perspectives are commissioned by the editorial team.Research areas covered in the journal include (but are not necessarily limited to):Analytical chemistryBiochemistryCatalysisChemical biologyChemistry educationElectrochemistryEnvironmental chemistryGreen chemistryIndustrial chemistryInorganic chemistryLaboratory safetyMaterials chemistryMedicinal chemistryNanotechnologyOrganic chemistryOrganometallic chemistryPhysical chemistryPolymer chemistryPhotochemistrySupramolecular chemistrySurface chemistryTheoretical chemistry