放射腫瘤學實踐的首要任務是提高放射腫瘤學實踐的質量。專業人員的目的是通過對新技術的討論和說明、對當前實踐的評估和案例報告的發表，記錄當前實踐的狀態，為那些從事培訓和繼續教育的從業者提供背景。PRO致力于為讀者提供“有目的”的強調知識的內容。

The overarching mission of Practical Radiation Oncology is to improve the quality of radiation oncology practice. PRO's purpose is to document the state of current practice, providing background for those in training and continuing education for practitioners, through discussion and illustration of new techniques, evaluation of current practices, and publication of case reports. PRO strives to provide its readers content that emphasizes knowledge "with a purpose."